Fig. 3: Changes in regional manifold eccentricity from pre- to post-stroke.

A Average regional eccentricity during pre-stroke imaging. At left, illustration of how eccentricity is calculated. Regional eccentricity along the manifold is computed as the Euclidean distance (dashed red line) from the manifold centroid (white circle with red border). Each brain region’s eccentricity is color-coded in the low-dimensional space. The eccentricity of three example brain region is highlighted (single data points bordered in black). At right, each brain region’s eccentricity is correspondingly color-coded on the macaque cortical surface. B Same as in (A), but for post-stroke eccentricity. Note that the same example three brain regions from (A) are also highlighted. C Pairwise contrast of eccentricity from pre- to post-stroke. Positive (red) and negative (blue) values denote increases and decreases in eccentricity (i.e., expansion and contraction along the cortical manifold), respectively. D Significant changes from (A), following FDR correction for region-wise paired t-tests (at q < 0.05).