Fig. 4: Multiregion sequencing of nine copy number alteration (CNA)-quiet oral cavity SCC (OCSCC) to analyze CNA intratumor heterogeneity. | Nature Communications

Fig. 4: Multiregion sequencing of nine copy number alteration (CNA)-quiet oral cavity SCC (OCSCC) to analyze CNA intratumor heterogeneity.

From: Hallmarks of a genomically distinct subclass of head and neck cancer

Fig. 4

a Fraction genome altered (FGA, y-axis) across multiple biopsies (n = 3 biopsies per tumor, except for sample 477: n = 2 biopsies) from n = 9 CNA-quiet OCSCCs (x-axis). Data are presented as mean and error bars represent standard deviation. b–d Representative copy number plots of sample (b) 264, (c) 177 and (d) 422. Segments are shown in gray and highlighted in red when called, as output from low coverage whole genome sequencing (lcWGS). Source data are provided with this paper.

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