Fig. 6: Clinical and histological comparison between copy number alteration (CNA)-quiet (n = 73) and -other (n = 729) oral cavity SCC (OCSCC).

a Age at diagnosis for CNA-quiet and -other OCSCC. p-value was obtained using a two-sided Mann-Whitney test. Box shows the interquartile range (IQR) and median (64 yrs for CNA-quiet; 74 yrs for CNA-other). Whiskers extend to 1.5xIQR; outliers are individual points. b–f, Relative frequencies and number of patients are depicted in the bar graph per category of (b) sex, (c) tobacco use, (d) differentiation grade, (e) invasion pattern, (f) pattern of invasion (POI) scored as reported by Heerema et al.¹⁸, in a comparative study the POI of 26 CNA-quiet OCSCC was analyzed and compared with 52 T-stage matched CNA-other OCSCC, Chi-squared test comparing POI1-3 with POI4-5, (g) disease-stage, and (h) anatomical subsite in CNA-quiet and -other groups. Unknowns were excluded from the analysis. Disease-stage according to TNM classification 8th edition, 2017. Pathological stage was used when available; when the patient was not treated with surgery, clinical stage was used. p-values were obtained using a Chi-squared test. i Kaplan-Meier curve for CNA-quiet (n = 69) and -other OCSCC (n = 680) with p-value and hazard ratio (HR) displayed, obtained by log-rank test. Patients with curative treatment intent were included in the survival analysis; patients with palliative intent (n = 4 CNA-quiet and n = 49 CNA-other) were excluded. Source data are provided with this paper.