Fig. 6: MLL oncoprotein dynamics influence target gene expression during B-ALL-to-AML lineage-switching events.
From: MLL oncoprotein levels influence leukemia lineage identities
a Boxplot comparing the relative expression of the B-ALL-specific oncoprotein target genes in a cohort of 6 B-ALL (gold) and AML (pink) patient-matched samples that underwent a lineage-switching event as described in Tirtakusuma et al. ref. 10. p values were calculated using a one-sided Wilcoxon sign-rank test, n = 66 genes; boxplot center lines = median, box limits = first and third quartiles, whiskers = 1.5 times the interquartile range (IQR). b Same as (a) but comparing the relative expression of the 51 genes in the GMP-like program, n = 51; boxplot center lines = median, box limits = first and third quartiles, whiskers = 1.5 times the interquartile range (IQR). c At high levels the MLL oncoprotein reinforces the B-ALL identify by activating a lymphoid program. During lineage switching the oncoprotein levels are reduced, and the oncoprotein activates a GMP-like program.
