Fig. 8: KMT2C and GMP gene expression changes during menin inhibitor treatment.

a Expression of the KMT2C gene is significantly reduced in the lineage-switching sample treated with the menin inhibitor. Bar height is the average of three qPCR biological replicates; Error bars = standard deviation; p value computed using a two-tailed independent samples t-test; n = 3 qPCR biological replicates. b The menin-inhibitor-resistant AML patient P9 sample has significantly higher expression of the GMP-like program than two menin-inhibitor responder samples and one additional non responder profiled in Perner et al. 2023 (ref. ¹⁶). p values were computed using the two-sample t-test for independent samples. For comparisons of samples classified as non-responders to responders we used a one-sided test, otherwise we used a two-sided test. n is the number of GMP-like genes that had a significant fold change between the menin-inhibitor treated and untreated samples (padj. < 0.05): MV4;11 = 30, PDX3 = 28, PDX4 = 32, P9 = 39; boxplot center lines = median, box limits = first and third quartiles, whiskers = 1.5 times the interquartile range (IQR). Source data are provided as a Source Data file.