Fig. 1: Schematic illustration of the synthesis and fungicidal mechanism of PCW nanoflowers. | Nature Communications

Fig. 1: Schematic illustration of the synthesis and fungicidal mechanism of PCW nanoflowers.

From: Synergistic wall digestion and cuproptosis against fungal infections using lywallzyme-induced self-assembly of metal-phenolic nanoflowers

Fig. 1

The PC nanopetals are firstly synthesized via the ont-pot coordination self-aasembly of PA and Cu2+. PCW nanoflowers are then obtained by Lwy induced self-assembly of PC nanopetals. PCW nanoflowers can be decomposed in acidic microenvironment, leading to the release of Cu2+ and Lyw. After incubated with fungal cells, PCW nanoflowers can adhere to the fungal surface. Lyw is then released to digest the dense fungal cell walls. A large amount of Cu2+ is internalized into the fungal interior to induce fungal cuproptosis. PCW nanoflowers are also expected to destroy mature fungal biofilms. The in vivo fungicidal effect of PCW nanoflowers is confirmed by a murine skin fungal infection model and a murine fungal keratitis model.

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