Fig. 8: The in vivo antifungal ability of PCW on a C. albicans induced keratitis model. | Nature Communications

Fig. 8: The in vivo antifungal ability of PCW on a C. albicans induced keratitis model.

From: Synergistic wall digestion and cuproptosis against fungal infections using lywallzyme-induced self-assembly of metal-phenolic nanoflowers

Fig. 8

a Real-time ocular fluorescence imaging of RhoB and PCW@ RhoB at different time points. b Fluorescent intensity decay curves of RhoB and PCW@ RhoB in the eye area over time. c Schematic diagram of murine keratitis infection with C. albicans and treatment protocol with different formulations. d Slit lamp photos of eyes after different treatments on the 1st, 2nd, 3rd, 6th, 7th, 9th, and 12th day. e Ocular clinical scores after different treatments. f C. albicans colony counting of corneal tissue after different treatments on the 6th day. g SEM images of corneal tissues after different treatments on the 12th day. f, g showed one of three independent experiments with similar results. Data for (b, e, f) were presented as mean values ± SD (n = 3 independent experiments). error bars = SD. Significance of (b) was calculated by two-sided Student’s t-test. Significance of (f) was calculated by one-way ANOVA with Tukey’s post hoc test. Source data were provided in Source Data file.

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