Fig. 4: Single-nuclei transcriptomes of cardiac tissue for genes increasing the risk of cardiomyopathy. | Nature Communications

Fig. 4: Single-nuclei transcriptomes of cardiac tissue for genes increasing the risk of cardiomyopathy.

From: Multi-trait association analysis reveals shared genetic loci between Alzheimer’s disease and cardiovascular traits

Fig. 4

A The transcriptomes form discrete cell-specific clusters using Uniform Manifold Approximation and Projection (UMAP). B Expression of PLEC and C1Q genes across cell-specific clusters from UMAP. Red indicates higher expression. C Enriched pathways of the PLEC-containing module in cardiovascular endothelial cells between dilated cardiomyopathy cases and healthy controls (P-values are derived from two-sided statistical tests). D Enrichment of pathway genes in the protein interactomes of candidate genes in cardiovascular endothelial cells. The PLEC-interacting module is the brown and the C1q-interacting module is the pink.

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