Fig. 5: Single-nuclei transcriptomes of human post-mortem brains for genes increasing the risk of Alzheimer’s disease. | Nature Communications

Fig. 5: Single-nuclei transcriptomes of human post-mortem brains for genes increasing the risk of Alzheimer’s disease.

From: Multi-trait association analysis reveals shared genetic loci between Alzheimer’s disease and cardiovascular traits

Fig. 5

A The transcriptomes form discrete cell-specific clusters using Uniform Manifold Approximation and Projection (UMAP). B Expression of candidate genes across cell types in human brain. C Enriched pathways of the PLEC-containing module in astrocytes between Alzheimer’s disease cases and healthy controls (P-values are derived from two-sided statistical tests). D Enrichment of pathway genes in the protein interactomes of candidate genes in astrocytes. The PLEC-interacting module is the cyan and the NDUFS3-interacting module is the dark red. Astro Astrocytes, Exc Excitatory Neuron, Inh Inhibitory Neuron, Micro Microglia, Oligo Oligodendrocytes, OPC Oligodendrocytes Progenitor Cells, Vasc Vascular cells.

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