Fig. 4: Effect of antibiotic treatment on phage diversity. | Nature Communications

Fig. 4: Effect of antibiotic treatment on phage diversity.

From: The phageome of patients with ulcerative colitis treated with donor fecal microbiota reveals markers associated with disease remission

Fig. 4

LOTUS vOTUs that were classified as a virus (n = 25941) were included in the analysis. A Margalef’s (species) richness in patients at baseline (Baseline, n = 31) and patients following antibiotic treatment (Post Abx, n = 32). Differences were tested using a two-sided Mann–Whitney test (p < 0.0001) following assessment of normal distribution with Shapiro-Wilk test (Baseline: p = 0.0102, Batches: p < 0.0001). Errors are ± SEM. B Principal coordinate analysis (PCO) on Aitchinson distances between patients at baseline (Baseline, green) and patients following antibiotic treatment (Post Abx, purple). Differences between groups were tested using PERMANOVA and PERMDISP. C Volcano plot of differential abundance analysis of vOTUs between patients at baseline (Baseline) and patients following antibiotic treatment using ZicoSeq. 408 vOTUs were identified to be significantly differentially abundant between groups. D Classification of vOTUs that were significantly differentially abundant. Legend is % prevalence. Source data are provided as a Source Data file.

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