Fig. 1: Distinct myonuclear populations are associated with times of cell fusion. | Nature Communications

Fig. 1: Distinct myonuclear populations are associated with times of cell fusion.

From: Lineage tracing of nuclei in skeletal myofibers uncovers distinct transcripts and interplay between myonuclear populations

Fig. 1

a Uniform Manifold Approximation and Projection (UMAP) visualization represents seven color-coded myogenic nuclei clusters identified by snRNA-seq. Data were generated from tibial anterior (TA) muscles at postnatal (P) day 10. b Dot plot depicting canonical markers of the various myogenic states. Dot size denotes the percentage of nuclei expressing the gene. c PHATE trajectory illustrating myogenic populations presented in (a) (left), with Dev. 1 and Dev. 2 populations highlighted in the same PHATE plot on the right. d Heatmap of myogenic nuclei from P10 TA muscle shows a distinct transcriptional signature. e Integrated dataset displays myogenic nuclei from TA muscle at P10 and 5 months of age (Split UMAP view). f Dot plot demonstrates altered genes in Dev. myonuclei. Dot size denotes the percentage of nuclei expressing the gene. Pink bar indicates genes that are increased in Dev nuclei compared to MuSCs and decreased in other myonuclear populations at P10 and 5 months of age. Purple bar indicates genes expressed in Dev nuclei but at a reduced level compared to MuSCs. Gray bar highlights genes that are similarly expressed across myonuclear populations.

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