Fig. 5: Mice lacking GLTP in oligodendrocytes exhibit hypomyelination and dysmyelination.
From: Nonvesicular lipid transfer drives myelin growth in the central nervous system
a Optic nerve of Gltp cKO and Cre control mice at P28. b, c g-ratio (a measurement of myelin thickness defined as inner diameter of myelin divided by outer diameter), quantification from three mice for each condition. b shows g-ratio of individual myelin relative to the enwrapped axon’s diameter. c shows the mean of myelin g-ratio from each mouse, showing mean \(\pm \,\)SD, Cre: 0.754\(\pm\)0.015, cKO: 0.783\(\pm\)0.003 (n = 3 mice for each condition, Two-tailed unpaired t-test, t = 3.282, df=4, *p = 0.0304) d mean of inner tongue diameter from three mice for each condition, showing mean \(\pm \,\)SD, Cre: 0.080\(\pm\)0.004 µm, cKO: 0.107\(\pm\)0.016 µm. (n = 3 mice for each condition, Two-tailed unpaired t-test, t = 2.943, df=4, *p = 0.0422) e examples of myelin whorls f Ratio of myelin whorls, showing mean \(\pm \,\)SD, Cre: 0.424\(\pm\)0.170%, cKO: 2.852\(\pm\)0.425% (n = 3 mice per condition, Two-tailed unpaired t-test, t = 9.203, df=4, ***p = 0.0008). g Percentage of axons that are myelinated, showing mean \(\pm \,\)SD, Cre: 83.720\(\pm\)6.148%, cKO: 76.780\(\pm\)11.43% (n = 3 mice per condition, two-tailed unpaired t-test). Scale bars: 1 µm (a and e). Source data are provided as a Source Data file.
