Fig. 6: The biological functions affected by structural changes of composed proteins.
From: Using in vivo intact structure for system-wide quantitative analysis of changes in proteins
A–C Structural changes of proteins enriched in generation of precursor metabolite and energy (A), carbon metabolism (B), and metal ion homeostasis (C) are shown. The heatmap (top) showed variations in the fold-change of the accessibility based on peptide sequence. The scatter plots (bottom) were plotted irrespective of peptide sequences. The p-value was calculated using Student’s t-test. D–F Expression change of proteins enriched in generation of precursor metabolite and energy (D), carbon metabolism (E), and metal ion homeostasis (F). The fold-changes of the expression level are presented. Three mice per age were used for both NC and AD. Error bars indicate the mean ± standard deviation. P-values from two-sided Mann-Whitney test are shown between the indicated groups. Source data are provided as a Source Data file.
