Fig. 6: Distribution of genes, pair-wise Z score and heterogeneity test of MR estimates across different activation time points. | Nature Communications

Fig. 6: Distribution of genes, pair-wise Z score and heterogeneity test of MR estimates across different activation time points.

From: Transcriptome-wide Mendelian randomization during CD4+ T cell activation reveals immune-related drug targets for cardiometabolic diseases

Fig. 6

a Proportion of the 162 T2D genes and 80 CAD genes by activation status and five time points. b Example genes that showed distinguish causal effects across activation time points. Effect estimates were odds ratio and 95% confidence interval of disease risk per unit change of the expression levels of the relevant gene. The error bars represent 95% confidence intervals. c Pair-wise Z score of gene–disease pairs across different activation time points. X-axis is Z-score from two-sided pair-wise Z test with degree of freedom of one. The Y-axis is minus log 10 P value of the pair-wise Z test. d Number and two-sided Fisher’s exact test of gene-disease pairs with or without robust MR evidence and time point-specific effects.

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