Fig. 7: CYP5122A1 overexpression confers resistance to a subset of CYP5122A1 inhibitors. | Nature Communications

Fig. 7: CYP5122A1 overexpression confers resistance to a subset of CYP5122A1 inhibitors.

From: CYP5122A1 encodes an essential sterol C4-methyl oxidase in Leishmania donovani and determines the antileishmanial activity of antifungal azoles

Fig. 7

Log phase promastigotes were inoculated in various concentrations of DB766 (A), fluconazole (B), posaconazole (C) or clotrimazole (D); and culture densities were determined after 48 hours. Percentages of growth were indicated relative to control cells grown in the absence of inhibitors. Symbols and error bars represent the means and standard deviations from three independent repeats. Two-tailed ANOVA without adjustment (*p < 0.05, ***p < 0.001). Source data are provided as a Source Data file.

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