Fig. 1: IFITM3 deficiency lowers the minimum infectious dose threshold for avian influenza viruses in vivo.
From: Innate immune control of influenza virus interspecies adaptation via IFITM3
WT and Ifitm3−/− mice were intranasally infected with (a–c) 1, 10, or 50 TCID50 of H5N1 avian influenza strain (2 independent experiments for doses 1 and 10 (n = 10 mice) and 1 experiment for dose of 50 (n = 5 mice)) or with (d–f) 1 or 10 TCID50 of H7N3 avian influenza strain (n = 5 mice). a, d Viral titers from lung homogenates at day 3 post infection. b, e ELISA quantification of IL-6 levels in lung homogenates at day 3 post infection. c, f ELISA quantification of IFNβ levels in lung homogenates at day 3 post infection. All error bars represent SEM. Comparisons were analyzed by one-way ANOVA followed by Tukey’s multiple comparisons test. Only comparisons between WT and Ifitm3−/− mice for each dose are shown. a–f Each data point represents an individual mouse. The numbers shown above the graph represent exact p-values. Source data are provided as a Source Data file.
