Fig. 7: Proposed model for ribosome biogenesis regulation by DDX10 in mESCs. | Nature Communications

Fig. 7: Proposed model for ribosome biogenesis regulation by DDX10 in mESCs.

From: DEAD-box RNA helicase 10 is required for 18S rRNA maturation by controlling the release of U3 snoRNA from pre-rRNA in embryonic stem cells

Fig. 7

A schematic working model illustrating the mechanism of DDX10 in regulating ribosome biogenesis. In the presence of DDX10, it functions as a component of the SSU processome within the nucleolus, facilitating the release of U3 snoRNA from pre-rRNA. This activity ensures the maturation of 18S rRNA and the biogenesis of the 40S subunits. In contrast, in the absence of DDX10, the release of U3 snoRNA from pre-rRNA is impaired, resulting in compromised maturation of 18S rRNA and impaired biogenesis of the 40S subunits.

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