Fig. 4: The impact of standard and mature nAbs on cases caused by DENV2 and DENV3.

The odd ratios and 95% confidence intervals of experiencing a case of DENV2 (diamonds) or DENV3 (inverted triangles) by baseline titer were measured with standard reference (A) or mature clinical (B) strains. N = number of individuals with and without DENV2 or DENV3 disease evaluated in each model. All analyses were logistic regression models adjusted for age, sex, and enrollment site, and inverse probability weighting was used to adjust for GMT and nAb subset sizes. Individual-level data and distributions (medians in red, boxes show interquartile ranges, whiskers extend to show the full range of the data) of baseline titers for monotypic and multitypic immune participants, stratified by those who experienced a case caused by each serotype or did not experience a case, shown separately for standard reference (C) or mature clinical (D) neutralization assay results. A Welch two-sample, two-sided t test was used to compare differences in titer means between cases and non-cases for each analysis, with p-values reported. The number of individuals who experienced a case with that serotype or did not have a case are shown as the denominator under each boxplot, while those in each category with titers above the assay threshold (shown as a dotted line, 1:20 for the mature and 1:40 for the standard assay) are indicated in the numerator. Source data are provided as a Source Data file.