Fig. 8: Loss of eat-17 likely affects the proprioceptive function of the PVD neurons.

a Representative images to show the moving tracks of wildtype, dma-1(wy686), eat-17(ok2983) and eat-17(ok2983) Ex[skin::eat-17f] at 1 day old adult stage. Scale bar, 100 μm. b Quantification of the body length for the strains showed in (a). n = 10 animals were quantified for each genotype. All values are presented as mean ± s.e.m. ns: not significant (one-sided ANOVA with the Tukey correction). c, d Quantification of amplitude (c) and wavelength (d) of the moving tracks for the genotypes indicated (n = 11 animals for each genotype). All values are presented as mean ± s.e.m. ns: not significant, *p < 0.05, ****p < 0.0001 (one-sided ANOVA with the Tukey correction). e A cartoon to show that EAT-17 acts together with BICD-1, the dynein complex and other endocytosis regulators to promote SAX-7 endocytosis from the lateral plasma membranes. The endocytosed SAX-7 is delivered into the lysosomal degradation pathway or potentially recycled back to the plasma membranes. For (b–d) source data are provided as a Source Data file.