Fig. 3: Examining the convergence of differentially edited sites across organ systems.

a Schematic depicting the site-specific RNA editing analysis pipeline for developmental bulk organ samples. After bulk organ samples were grouped into prenatal and postnatal groups, differential editing analysis was conducted between these two developmental groups. Finally, an analysis was conducted to find shared and unique differentially edited sites between organs. b Venn diagram illustrating the number of shared and unique prenatal versus postnatal differentially edited sites across all examined organ datasets. c GO term functional annotation of the pan-organ shared differentially edited sites. D List of the input genes that are associated with these corresponding convergent GO terms. e–j Charting global A-to-I editing dynamics (AEI), along with the Viral Infection and DNA replication pathway gene scores, across developmental time, for the forebrain (e), hindbrain (f), heart (g), liver (h), kidney (i), and testis (j). Correlation between the gene score sets and the AEI was measured using the Pearson correlation coefficient.