Fig. 5: Single nuclei RNA editing analysis across teratoma development.
From: Charting and probing the activity of ADARs in human development and cell-fate specification
a Workflow schematic for running single nuclei RNA editing analysis across teratoma development. b Aggregated and downsampled UMAP plots from H1 teratomas across weeks 4–10 of development, processed through the single-cell RNA sequencing pipeline. 2–5 teratoma samples were processed for each time point. UMAP plots are downsampled so the total number of cells plotted is consistent across all time points. c AEI values for all teratoma cell-types across development. d Pan germ-layer correlation between teratoma cell-types and corresponding cell-types from the Human Fetal Cell Atlas database. e Transcriptomic correlation between time series teratomas and time-resolved human fetal cortex data between Gestational Weeks (GW) 14-19. f RNA editing rate, via AEI, correlation between time series teratomas and time-resolved human fetal cortex data between GW14–19.
