Fig. 6: Schematic model of enhanced DNA damage-responsive gene expression mediated by H3K56ac-BAF complex interaction. | Nature Communications

Fig. 6: Schematic model of enhanced DNA damage-responsive gene expression mediated by H3K56ac-BAF complex interaction.

From: The BAF complex enhances transcription through interaction with H3K56ac in the histone globular domain

Fig. 6

Upon DNA damage (depicted by red-colored DNA), the tumor suppressor p53 is induced and binds to p53-responsive elements in the promoters of DNA damage-responsive genes. p53 recruits transcriptional coactivators, including histone acetyltransferases (HATs) such as p300 and CBP, to these promoter regions through direct interactions. HATs acetylate H3K56 located on the lateral surface of the histone globular domain. The chromatin remodeler BAF complex recognizes H3K56ac via the DPF domain in the DPF2 subunit and facilitates nucleosome remodeling around the promoter regions, thereby leading to enhanced gene expression. HATs also acetylate multiple lysine residues on histones and transcription factors (not depicted), further promoting efficient transcription.

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