Fig. 7: Schematic illustration of the functional mechanism of DHX36-induced structure change in regulating the activity of YTHDF1 binding and target mRNA degradation. | Nature Communications

Fig. 7: Schematic illustration of the functional mechanism of DHX36-induced structure change in regulating the activity of YTHDF1 binding and target mRNA degradation.

From: DHX36 binding induces RNA structurome remodeling and regulates RNA abundance via m6A reader YTHDF1

Fig. 7

DHX36 binds to and resolves the structured sites. The increased structural accessibility of DHX36-bound m6A sites promotes m6A- dependent YTHDF1 binding to promote target mRNA degradation. Created in BioRender. Zhang, Y. (2023) BioRender.com/u61b678.

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