Fig. 8: The expression of NRAS Q61R/K mutants positively correlates with USP46 and CK1δ in melanoma. | Nature Communications

Fig. 8: The expression of NRAS Q61R/K mutants positively correlates with USP46 and CK1δ in melanoma.

From: Pharmacological targeting of casein kinase 1δ suppresses oncogenic NRAS-driven melanoma

Fig. 8

a Representative images of immunohistochemical staining of USP46, CK1δ and NRAS in tumor samples of melanoma harboring NRAS Q61R (n = 19) or NRAS Q61K (n = 16). b Correlation of NRAS Q61R/K expression with USP46 and CK1δ was analyzed, respectively. Significant correlations were determined using a two-tailed Pearson correlation (n = 35). c This working model to illustrate that CK1δ phosphorylation-dependent activation of USP46 regulates tumorigenesis proliferation, migration, invasion and chemoresistance through stabilizing NRAS Q61R/K mutant.

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