Fig. 6: Model for the role of rs6048205 in pancreatic differentiation and glycemia homeostasis. | Nature Communications

Fig. 6: Model for the role of rs6048205 in pancreatic differentiation and glycemia homeostasis.

From: A noncoding variant confers pancreatic differentiation defect and contributes to diabetes susceptibility by recruiting RXRA

Fig. 6

The noncoding SNP rs6048205 risk allele G enhances RXRA binding and activates FOXA2 expression, specifically in the pancreatic progenitor stage. The rs6048205 risk allele G reduces the differentiation efficiency of NKX6-1+ pancreatic progenitor cells, leading to a decrease in functional β cells and an abnormal increase in polyhormonal endocrine cells in vitro. Mice carrying the risk allele G exhibit higher fasting glucose levels and impaired glucose tolerance, contributing to increased susceptibility to diabetes in vivo.

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