Fig. 3: Interactions of CB1R with peripheral inverse agonists.
From: Structural mechanism of CB1R binding to peripheral and biased inverse agonists
A Structural overlay of CB1R bound to MRI-1891 and MRI-1867. Receptor is shown as a gray cartoon. The two MRI compounds are displayed as sticks, with MRI-1891 in orange and MRI-1867 in purple. The inset shows a rotated extracellular view of the ligands binding to the receptor. B Detailed interactions between MRI-1891 and CB1R. Contact residues within 4 Å of MRI-1891 (orange sticks) are shown as gray sticks. C Detailed interactions between MRI-1867 and CB1R. Contact residues within 4 Å of MRI-1867 (purple sticks) are shown as gray sticks.
