Fig. 6: Overlap of MRI-1891 and taranabant bound in the CB1R orthosteric pocket. | Nature Communications

Fig. 6: Overlap of MRI-1891 and taranabant bound in the CB1R orthosteric pocket.

From: Structural mechanism of CB1R binding to peripheral and biased inverse agonists

Fig. 6

Superposition is based on all receptor Cα positions (rmsd 0.6 Å). The MRI-1891 inverse agonist and selected sidechains from its complex are shown as orange sticks. Superimposed structure of taranabant and the same sidechains in its complex are shown as transparent gray sticks. Dotted line indicates base of the orthosteric pocket.

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