Fig. 1: Iterative approaches in synthesis and application in automation.
From: Reaction blueprints and logical control flow for parallelized chiral synthesis in the Chemputer
A Iterative building block approaches make use of very selective and efficient transformations. High selectivity and efficiency is generally imparted by specific functional groups in the building blocks. B Iterative MIDA/TIDA boronate chemistry. Use of building blocks containing halide and boronate ester enables selective coupling, purification over multiple cycles. C Iterative homologations enable chain-growth of target molecules. The product retains the required synthetic handle, boronic ester, for further coupling cycles.
