Fig. 4: Fully automated synthesis of catalysts (S)-Cat-1–3 in the Chemputer over uninterrupted 3-step sequence. | Nature Communications

Fig. 4: Fully automated synthesis of catalysts (S)-Cat-1–3 in the Chemputer over uninterrupted 3-step sequence.

From: Reaction blueprints and logical control flow for parallelized chiral synthesis in the Chemputer

Fig. 4

All syntheses involve preparation of a Grignard reagent in situ from the corresponding aryl halides and subsequent addition to proline derivative, acidic deprotection, and silyl ether formation. Different reagent inputs are provided into otherwise identical digital procedures for execution on an automated synthesis platform, allowing for convenient access to multi-gram quantities of chiral catalysts (S)-Cat-1–3.

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