Fig. 6: Synthetic applications utilizing χDL iterations, blueprints, and parallelization.
From: Reaction blueprints and logical control flow for parallelized chiral synthesis in the Chemputer
A Iterations over reagents, hardware, and parameters are possible through Repeat blocks. Different iteration modes, including combinatorial and flat iteration, can be combined to generate different experimental designs. All possible arrangements are described succinctly using nested Repeat blocks. B Parallelization through queues allows multiple independent operations to be run at the same time, as well as to describe prerequisites for each operation (arrows indicate control flow of the process). Pictured is a workflow for recycling an organocatalyst in an asymmetric Michael addition reaction. C Automated synthesis of several batches of Michael addition products with catalyst recycling. Combined use of iterations, blueprints, and parallelization enables multiple batches of the same product (left) or a small library of products (right) to be generated with a single dosage of the catalyst.
