Fig. 3: PHB and CNA START domains may help distinguish responsive from non-responsive shared binding sites.
From: START domains generate paralog-specific regulons from a single network architecture
a–f CNA vs CNA-SDΔ analyses (red vs pink). g–l PHB vs PHB-SDΔ analyses (blue vs cyan). a, g Histograms and heatmaps of ChIP-seq signal intensities. Lines on histograms delineate categories as described in Fig. 1. Heatmaps are separated into categories and subcategories as described in Fig. 1. b, h Venn diagrams of sites bound by wildtype and START-deleted variants. c, i Venn diagrams of genes bound by wildtype and START-deleted variants. d, j Venn diagrams of direct targets of wildtype and START-deleted variants, i.e. bound in ChIP-seq and differentially expressed in RNA-seq. Numbers in parentheses correspond to direct targets bound specifically by wildtype or START-deleted variants. e, k Scatterplots showing differential expression of genes bound and regulated by both wildtype and START-deleted variants. f Scatterplot showing differential expression of genes bound by both variants but uniquely regulated by CNA (red) or CNA-Delta (pink). l Scatterplot showing differential expression of genes bound by both variants but uniquely regulated by PHB (blue) or PHB-SDΔ (cyan).
