Fig. 5: Chimeric CNA proteins show widespread differential usage of shared binding sites.
From: START domains generate paralog-specific regulons from a single network architecture
a–f CNA vs CNA-SmHOX32 analyses (red vs green). g–l CNA vs CNA-PpHOX32 analyses (red vs orange). a, g Histograms and heatmaps of ChIP-seq signal intensities. Lines on histograms delineate categories as described in Fig. 1. Heatmaps are separated into categories and subcategories as described in Fig. 1. b, h Venn diagrams of sites bound by CNA and its chimeras. c, i Venn diagrams of genes bound by CNA and its chimeras. d, j Venn diagrams of direct targets of CNA and its chimeras, i.e. bound in ChIP-seq and differentially expressed in RNA-seq. Numbers in parentheses correspond to direct targets bound specifically by CNA or its chimeras. e, k Scatterplots showing differential expression of genes bound and regulated by both CNA and its chimeras. f Scatterplot showing differential expression of genes bound by CNA but uniquely regulated by CNA (red) or CNA-SmHOX32 (green). l, Scatterplot showing differential expression of genes bound by both variants but uniquely regulated by CNA (red) or CNA-PpHOX32 (orange).
