Fig. 5: Localized in vivo gene-editing reduces recurrence of B16F10 melanoma tumors in the surgical bed.
From: In vivo gene editing of T-cells in lymph nodes for enhanced cancer immunotherapy
(a) Schematic illustration of in vivo T-cell engineering treatment in an incomplete-surgery murine tumor model. The tumor growth (size) (b), survival curves (c), and body weights (d) after different treatments as indicated. For (b−d), n = 5 mice in each group. Log-rank tests were performed to analyse the overall survival. Cytokine concentrations of IFN-γ (e) and TNF-α (f) in the serum of mice on day 19 with different treatments. For (e, f), n = 4 mice in each group. The data are presented as mean ± s.e.m., analyzed using a one-way ANOVA with Tukey’s multiple comparison test. Source data are provided as a Source Data file.
