Fig. 7: Golgi-trapped CDC42 variants are associated with high IFNα levels in the blood. | Nature Communications

Fig. 7: Golgi-trapped CDC42 variants are associated with high IFNα levels in the blood.

From: Autoinflammatory patients with Golgi-trapped CDC42 exhibit intracellular trafficking defects leading to STING hyperactivation and ER stress

Fig. 7

Quantification of IFNα in sera or plasma from R186C (P1-4) and *192 C*24 (P5-6) CDC42 patients at the onset of the disease or after different treatments: P1 → 1: probable virosis (ongoing glucocorticoids and anakinra), 2: infection by adenovirus and rhinovirus (ongoing glucocorticoids, anakinra and cyclosporine), 3: ongoing cyclosporine, glucocorticoids and anakinra, 4: bone marrow transplantation. P2 → 1: high dose of glucocorticoids and anakinra. P3 → Onset: improved state. 1: Re-inflammatory state, anti-TNF treatment. P4 → 1: anakinra, 2: glucocorticoids and canakinumab. P5 → 1: anakinra, 2: high dose of anakinra. P6 → 1 and 2: corticosteroids and intravenous Ig (Immunoglobulin response therapy). Each dot represents the mean value of three technical replicates from one independent experiment. HDs measurements were performed in three or four biological replicates and the results are shown as means +/- SEM. Source data are provided as a Source Data file.

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