Fig. 7: Altered chromatin E-P loops in MAD-MSCs are implicated in stem cell aging. | Nature Communications

Fig. 7: Altered chromatin E-P loops in MAD-MSCs are implicated in stem cell aging.

From: Disorganized chromatin hierarchy and stem cell aging in a male patient of atypical laminopathy-based progeria mandibuloacral dysplasia type A

Fig. 7

a Statistical analysis of global changes in chromatin loop and enhancer-promoter loop. b The transcription changes of altered E-P loops in MAD-MSCs. All p-values were determined using the two-sided Wilcoxon rank-sum test. c Cross-analysis of the enrichment of dysregulated genes resulted from E-P loop alteration in MAD-MSCs with geroprotection/senescence-associated profile plotted by hMSCs aging models. Color depth indicates enrichment score. d Representative transcriptional dysregulation corresponds with strengthened and weakened E-P loops, respectively.

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