Fig. 5: The a09b08 ImmTAV elicits antigen-dependent T cell killing of target cells.
From: Viral sequence determines HLA-E-restricted T cell recognition of hepatitis B surface antigen
Apoptosis (measured by IncuCyte assay, see methods) of Env371-379 (L6I) Ag+ PLC/PRF/5 target cells wildtype (a) or HLA-E*01:03 lentiviral transduced (b), cocultured with HBV-naïve donor PBMC and a titration of a09b08 ImmTAV. Dashed vertical lines indicate timepoints from which target cell apoptosis begins (at 1 nM ImmTAV). Results (a, b) are representative of one of three PBMC donors, each tested in triplicate. Data were presented as mean values ± SD. Source data are provided as a Source Data file.
