Fig. 3: Clonal diversity and evolution of recurrent somatic mutations. | Nature Communications

Fig. 3: Clonal diversity and evolution of recurrent somatic mutations.

From: Whole-exome sequencing reveals genomic landscape of intrahepatic cholangiocarcinoma and identifies SAV1 as a potential driver

Fig. 3

A Clonal diversity quantified and sorted by Shannon index in 204 ICCs. B Kaplan–Meier survival analysis showing overall survival and recurrence-free survival based on the Shannon index (clonal equilibrium and clonal dominance). P: log-rank test, two-sided. C Evolution of recurrent mutations in likely cancer driver genes. Patients are ordered by the total number of non-synonymous mutations; recurrent mutations are sorted by proportion defined as trunk and overall frequency. The cancer cell fraction (CCF) measures the proportion of the tumor population that harbors the mutation. TNM tumor node metastasis, LN lymph node, CCF cancer cell fraction.

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