Table 1 Clinicopathologic characteristics of patients with intrahepatic cholangiocarcinoma
Variable | WES (n = 204) | Sanger sequencing (n = 468) | |||
|---|---|---|---|---|---|
N | % | N | % | ||
Age (year) | ≤50 | 41 | 20.1 | 84 | 17.9 |
>50 | 163 | 79.9 | 384 | 82.1 | |
Sex | Female | 82 | 40.2 | 200 | 42.7 |
Male | 122 | 59.8 | 268 | 57.3 | |
HBsAg | Negative | 137 | 67.2 | 324 | 69.2 |
Positive | 67 | 32.8 | 144 | 30.8 | |
Liver fluke | Negative | 193 | 94.6 | 437 | 93.4 |
Positive | 11 | 5.4 | 31 | 6.6 | |
CA19-9 | ≤36 | 94 | 46.1 | 198 | 42.3 |
>36 | 110 | 53.9 | 270 | 57.7 | |
GGT(U/L) | ≤54 | 110 | 53.9 | 232 | 49.6 |
>54 | 94 | 46.1 | 236 | 50.4 | |
Liver cirrhosis | No | 148 | 72.5 | 353 | 75.4 |
yes | 56 | 27.5 | 115 | 24.6 | |
Tumor size(cm) | ≤5 | 100 | 49.0 | 216 | 46.2 |
>5 | 104 | 51.0 | 252 | 53.8 | |
Tumor number | Single | 157 | 77.0 | 339 | 72.4 |
Multiple | 47 | 23.0 | 129 | 27.6 | |
Microvascular/Bile duct invasion | No | 156 | 76.5 | 372 | 79.5 |
Yes | 48 | 23.5 | 96 | 20.5 | |
Lymphatic metastasis | No | 176 | 86.3 | 399 | 85.3 |
Yes | 28 | 13.7 | 69 | 14.7 | |
Tumor encapsulation | complete | 32 | 15.7 | 69 | 14.7 |
none | 172 | 84.3 | 399 | 85.3 | |
Tumor differentiation | I + II | 86 | 42.2 | 211 | 45.1 |
III + IV | 118 | 57.8 | 257 | 54.9 | |
TNM stage | I | 109 | 53.4 | 246 | 52.6 |
II | 65 | 31.9 | 144 | 30.8 | |
III | 29 | 14.2 | 73 | 15.6 | |
IV | 1 | 0.5 | 5 | 1.1 | |
