Fig. 8: Inhibition of FASN-mediated lipid synthesis mitigates HMGA1-promoted CRC tumorigenesis. | Nature Communications

Fig. 8: Inhibition of FASN-mediated lipid synthesis mitigates HMGA1-promoted CRC tumorigenesis.

From: High mobility group A1 (HMGA1) promotes the tumorigenesis of colorectal cancer by increasing lipid synthesis

Fig. 8

Rosa26Hmga1/+ and Hmga1IEC-OE/+ mice were treated with AOM/DSS for the induction of CRC. Orlistat (50 mg/kg) was applied to the mice by gavage every other day for the entire duration in the CRC induction. a, d Schematic diagram of the induction and orlistat treatment. b, e Representative images of colorectum in the mice. c, f The number and size of tumors in the entire colorectum of each mouse were measured. g, i HE staining of colorectum (CRC) from mice treated with control (water), AOM/DSS, orlistat, and AOM/DSS and orlistat (Scale bar = 20 μm. Representative images from 3 independent experiments). The percentage of LGD, HGD, and carcinoma was determined. LGD, low-grade dysplasia; HGD, high-grade dysplasia. h, j Representative images of IHC staining of Ki67 in colorectum (CRC) from the mice (Scale bar = 20 μm). Data are presented as mean ± SD. Statistical significance was determined by two-tailed unpaired t-test (c, f, h, j). n = 12. Source data are provided as a Source Data file.

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