Fig. 1: Structural organization of human Atg8 family proteins and reported binder. | Nature Communications

Fig. 1: Structural organization of human Atg8 family proteins and reported binder.

From: Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets

Fig. 1

a Left panel depicting the LIR docking site (LDS) of LC3A comprised of hydrophobic pocket 1 (HP1) in pink and hydrophobic pocket 2 (HP2) in orange. Right panel displaying the UIM docking site (UDS) in blue/cyan (PDB ID 3ECI). b Dihydronovobiocin bound to LC3A with an enlarged panel of the binding interface by interactions towards K49 and L53 and binding to the HP2 via hydrophobic interactions (PDB ID 6TBE). c Chemical structures of compounds, published to bind to LC3/GABARAPs with exemplary structures shown with all structures depicted in Supplementary Fig. 1.

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