Fig. 4: The TCR repertoire of NKG2A+ DP CD8 overlaps with NKG2A− DP CD8 T cells. | Nature Communications

Fig. 4: The TCR repertoire of NKG2A+ DP CD8 overlaps with NKG2A− DP CD8 T cells.

From: IL-12 drives the expression of the inhibitory receptor NKG2A on human tumor-reactive CD8 T cells

Fig. 4

a Circos plot of unique productive TCRβ nucleotide sequence for each of the indicated cell populations. Connections highlight sequences from NKG2A+ DP CD8 found in the other CD8 T cell populations. The number of shared sequences is indicated. b Similarities between the TCR repertoires of the different CD8 T cell subsets were measured using the Morisita-Horn index. c Scatter plot comparing the TCR repertoire of NKG2A− and NKG2A+ DP CD8 TILs. Each dot represents a unique TCR clonotype. Dots on either axis indicate clonotypes detected within a single repertoire; purple dots indicate clonotypes shared between the two CD8 T cell populations. This analysis was performed for 2 patients with HNSCC and 2 patients with CRC.

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