Fig. 8: Reactive capillary ECs in the lungs.
From: Endothelial Pim3 kinase protects the vascular barrier during lung metastasis
a Reactive capillary ECs (rCap) present in the lungs are increased in response to infiltrating tumor cells. rCap markers such as Pim3, Bcl3 and Inhbb mark the cancer reactive niche ECs in mouse, while rCaps in the human lungs express ICAM1. b JAK-STAT pathway target Pim3 enforces EC-EC junctions, while PIM kinase inhibition increases vascular leakage and metastatic colonization of the lungs. Illustration created in Biorender.com (a, b).
