Fig. 2: Neuronal gene expression and chromatin accessibility changes in fine brain regions. | Nature Communications

Fig. 2: Neuronal gene expression and chromatin accessibility changes in fine brain regions.

From: A multi-regional human brain atlas of chromatin accessibility and gene expression facilitates promoter-isoform resolution genetic fine-mapping

Fig. 2

a Volcano plot of RNA-seq data from fine brain regions in neuronal cells. Significant genes after FDR (Benjamini & Hochberg) correction (FDR < 0.05) are marked in red. The top 5 up- and down-regulated genes for each comparison are indicated. b Cell type, and pathway enrichment determined by one-tailed Fisher’s exact test in fine brain region-specific gene (for DEG)18 and OCR (for DAC)16 sets. Groups with a low number of significant differential results were masked and colored gray. Neu neuron. pyramidal SS somatosensory pyramidal cells. OPC oligodendrocyte progenitor cells. Odds ratio (OR). “·”: Nominally significant (P < 0.05); “+”: significant after FDR (Benjamini & Hochberg) correction (FDR < 0.05). Source data is provided as a Source Data file.

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