Fig. 6: Histopathological and immunohistochemical analysis.
From: Redox-switchable multicolor luminescent polymers for theragnosis of osteoarthritis
a H&E and safranin O/fast green staining of rat OA knee joints after different treatments. Scale bars: 200 μm. Each experiment was repeated three times independently with similar results. b Immunohistochemical staining of COL-2, AGG and MMP13. Scale bars: 200 μm. Each experiment was repeated three times independently with similar results. c–f The levels of TNF-α (c, ***P = 0.0008), IL-6 (d ***P = 0.0007), MMP-13 (e ***P = 0.0009), and GSH (f) in the synovial fluid after different treatments. Statistical significance: ***P < 0.001, ****P < 0.0001. Data are presented as the mean with SD (n  =  5) independent samples in (c–e) n  =  3 independent samples in (f). Statistical differences were analyzed by a one-way ANOVA with Tukey’s multiple comparisons test. ns means no significance.
