Fig. 1: An introduction to N-glycoconjugation of amines.
From: Stereoselective chemical N-glycoconjugation of amines via CO2 incorporation
A General illustration. B 1-O-glycosyl carbamates, a unique form of glycoconjugated amines, and its representative applications. C The role of a sugar moiety in the pharmacological activity of a N-glycomodified amine-containing drug. D Influence of anomeric configuration on the enzymatic cleavage of 1-O-glycosyl carbamates. E Previous strategies towards 1-O-glycosyl carbamates. F An interesting biotransformation pathway of amine-containing drugs in vivo. G This work: bioinspired stereoselective glycoconjugation of amines. R, functional group. UDPGA, uridinediphosphate glucuronic acid, UGT, uridine diphosphate glucuronosyl transferase, RT, room temperature.
