Fig. 4: Erythroderma and undetermined skin rashes display module profiles of AD, PsO, LP, and DHR sentinels.
From: Immune modules to guide diagnosis and personalized treatment of inflammatory skin diseases
a Module-based UMAP projection of erythroderma probes (grey circles) plotted against the established psoriasis (green circles), AD (blue circles), and DHR (red circles) cartography, showing disease-specific clustering. b Box plots showing immune module expression scores in erythroderma probes split by the sentinel disease (AD, n = 16; PsO, n = 10; or DHR, n = 4) they cluster with. Each dot represents one probe. c Module-based UMAP projection of undetermined rashes (grey circles) plotted against the established PsO (green circles), AD (blue circles), CLE (yellow circles), BP (turquoise circles), and DHR (red circles) cartography, showing disease-specific clustering. d Box plots showing immune module expression scores in erythroderma probes split by the sentinel disease (AD, n = 8; PsO, n = 10; LP, n = 2; or BP, n = 1) they cluster with. b and d, the central line of the box plot is the median. The box’s edges are the lower (25th percentile) and upper quartiles (75th percentile). Whiskers extend to data points within 1.5 times the interquartile range (IQR).
