Fig. 3: Deletion of MMR genes carries a significant cost to fitness.
a The fraction of Δmsh2, Δmsh6 and Δpms1 through time when in direct competition with the parental MFIG001 strain on solid agar faceted by media type (rich = aspergillus complete media, minimal = aspergillus minimal media). The coloured lines show the mean of 6 independent competitions, presented by individual grey lines. The horizontal dashed lines show the starting fraction of the MMR deletion strain. b Mean fitness of Δmsh2, Δmsh6 and Δpms1 relative to MFIG001 across the five transfers presented in panel a, the cross bar shows the median (N = 6 independent competitions), the lower and upper hinges correspond to the first and third quartiles and the whiskers extend to 1.5*IQR. Box plots coloured by media type. The horizontal dashed line shows equal fitness of zero, p-values show significant difference from zero using two-sided t-tests, using Holm correction for multiple testing, Δmsh2 rich P = 0.00023, minimal P = 4.8e−6, Δmsh6 rich P = 1, minimal P = 0.97, Δpms1 rich P = 0.025, minimal P = 0.00012, asterisks represent significance (*p < 0.05, **p < 0.01, ***p < 0.0001). Source data are provided as a Source Data file.
