Table 1 Natural isolates tested for changes in mutation rate

From: Elevated mutation rates in multi-azole resistant Aspergillus fumigatus drive rapid evolution of antifungal resistance

Strain

Source

Sample

cyp51A

Clade

pms1

msh2

msh6

ARAF005

Clinical

Sputum

Wild-type

B

Wild-type

Wild-type

Wild-type

C4

Environmental

Wheat field

TR34/L98H

B

Wild-type

Wild-type

Wild-type

C91

Environmental

Plant bulb

TR46/Y121F/T289A

B

Wild-type

Wild-type

Wild-type

C96

Environmental

Plant bulb

Wild-type

B

Wild-type

Wild-type

Wild-type

C127

Clinical

Sputum

Wild-type

B

Wild-type

Wild-type

Wild-type

C136

Clinical

Sputum

Wild-type

B

Wild-type

Wild-type

Wild-type

C169

Clinical

Sputum

Wild-type

B

Wild-type

Wild-type

Wild-type

C182

Clinical

Sputum

Wild-type

B

Wild-type

Wild-type

Wild-type

C272

Environmental

Unknown

Wild-type

B

M315V

Wild-type

Wild-type

ARAF001

Clinical

Sputum

TR34/L98H

A

E444G/S758Y

Wild-type

G233A

C1

Environmental

Soil

TR34/L98H

A

Wild-type

Wild-type

G233A

C6

Environmental

Soil

TR34/L98H

A

E444G

Wild-type

G233A

C7

Environmental

Soil

TR34/L98H

A

Wild-type

Wild-type

G233A

C12

Environmental

Soil

TR34/L98H

A

Wild-type

Wild-type

G233A

C21

Environmental

Soil

TR34/L98H

A

Wild-type

Wild-type

G233A

C79

Environmental

Compost

TR46/Y121F/T289A

A

Wild-type

K816Q

G233A/A1090S

C89

Environmental

Plant bulb

TR46/Y121F/T289A

A

Wild-type

E812G

Wild-type

C342

Environmental

Soil

TR34/L98H

A

E444G

Wild-type

G233A