Fig. 2: CD8+ exhausted T cells are present in the optic nerve of Nf1-OPG mice. | Nature Communications

Fig. 2: CD8+ exhausted T cells are present in the optic nerve of Nf1-OPG mice.

From: Human single cell RNA-sequencing reveals a targetable CD8+ exhausted T cell population that maintains mouse low-grade glioma growth

Fig. 2

A t-SNE visualization of scRNAseq data of optic nerves collected from 12-week-old Nf1-OPG mice, based on cell type; n = 10 pooled mice. Microglia and monocytes constitute tumor associated monocytes (TAM). B t-SNE visualization of the T cell populations from 12-week-old Nf1-OPG mouse optic nerves, color-coded by T cell type. NOS, not otherwise specified. C Dot plot showing the genes used to identify CD8+ exhausted T cells in 12-week-old Nf1-OPG mouse optic nerves. D Stacked bar plot representing the barcode frequency of the top clones in the different T cell populations in 12-week-old Nf1-OPG mouse optic nerves. The graph is color coded to show the 1–10 clones and 11–10,000 clones.

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