Fig. 9: ScRNA-seq profile of tumor cells. | Nature Communications

Fig. 9: ScRNA-seq profile of tumor cells.

From: A dendritic cell vaccine for both vaccination and neoantigen-reactive T cell preparation for cancer immunotherapy in mice

Fig. 9

a UMAP plots of the tumor cells, colored by cell type. b Proportions of each cell type in each group, colored by cell type. c Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of the different groups. d Circos plot of the CNV regions in different groups. e Circle plot showing the cellular crosstalk between tumor cells and other types of cells in the tumor microenvironment, comparing the OCDC + NRT group with the other groups. Pink represents upregulated cell communication in the OCDC + NRT group compared to the other groups, while purple represents specific cell communication in the OCDC + NRT group compared to the other groups. f Methodology for detecting somatic mutations in high-throughput single-cell profiling datasets (Created in BioRender. Min, D. (2024) https://BioRender.com/g96q664). g Oncogenic driver gene mutations and neoantigen mutations in cancer cells of the NS group. h Bar charts on the left showing the ratio of neoantigen mutations in each group, table on the right showing the count of mutant neoantigens and wild type neoantigens in each group. Source data are provided as a Source Data file.

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